Preeclampsia Treatment Englewood CO

Researchers already knew that changes in the concentrations of two proteins—placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFit1)—keyed the onset of milder forms of preeclampsia but did not seem to cause the life'threatening levels of high blood pressure seen in severe cases.

Arthur S Waldbaum MD
(303) 298-0222
1201 E 17th Ave
Denver, CO
Specialties
Obstetrics & Gynecology

Data Provided by:
Gretchen A Frey
(303) 744-3477
499 E Hampden Ave
Englewood, CO
Specialty
Gynecology / Oncology

Data Provided by:
Carolyn Frank Abman, MD
(303) 795-0890
601 E Hampden Ave
Englewood, CO
Specialties
Obstetrics & Gynecology
Gender
Female
Education
Medical School: Northwestern Univ Med Sch, Chicago Il 60611
Graduation Year: 1980
Hospital
Hospital: Swedish Med Ctr, Englewood, Co
Group Practice: Women's Healthcare Assoc

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Michele M McGould
(303) 788-7888
601 E Hampden Ave
Englewood, CO
Specialty
Obstetrics & Gynecology

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Kevin P Davis
(303) 781-9090
701 E Hampden Ave
Englewood, CO
Specialty
Obstetrics & Gynecology, Gynecology / Oncology

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Andrew McBride, MD
(303) 837-7682
2005 Franklin St
Denver, CO
Business
Mountain States Urogynecology
Specialties
Obstetrics & Gynecology

Data Provided by:
Eric Shire Surrey, MD
(303) 788-8300
799 E Hampden Ave Ste 300
Englewood, CO
Specialties
Obstetrics & Gynecology, Reproductive Endocrinology
Gender
Male
Education
Medical School: Univ Of Pa Sch Of Med, Philadelphia Pa 19104
Graduation Year: 1981

Data Provided by:
Mary Jo Schmitz
(303) 781-9090
701 E Hampden Ave
Englewood, CO
Specialty
Gynecology / Oncology

Data Provided by:
Robert Bennett Gore, MD
(303) 795-0890
601 E Hampden Ave Ste 370
Englewood, CO
Specialties
Obstetrics & Gynecology
Gender
Male
Education
Medical School: Univ Of Southern Ca Sch Of Med, Los Angeles Ca 90033
Graduation Year: 1978

Data Provided by:
Cynthia L Martin
(303) 788-1325
701 E Hampden Ave
Englewood, CO
Specialty
Obstetrics & Gynecology

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Early Warning Signs of Preeclampsia

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By Kathryn Ayers

High blood pressure, fluid retention, and excess protein in the urine all signal the onset of preeclampsia, a condition that affects one in 20 women during the third trimester of pregnancy. While a cause for concern in all cases—about 200,000 women suffer from preeclampsia in the US each year, and it is a leading cause of premature births—only those women who experience large and sudden increases in blood pressure face the threat of severe complications for themselves and their fetuses.

Researchers already knew that changes in the concentrations of two proteins—placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFit1)—keyed the onset of milder forms of preeclampsia but did not seem to cause the life-threatening levels of high blood pressure seen in severe cases. Their new study in The New England Journal of Medicine names a third factor, soluble endoglin, that seems to kick preeclampsia into overdrive. This protein, which the researchers found in high concentrations in the placentas of women with severe preeclampsia, normally helps maintain the blood vessels, but when it sloughs off the blood vessel walls and combines with sFit1, it actually weakens them.

The study reports that soluble endoglin levels begin to increase markedly two to three months before the onset of preeclampsia and that this increase is usually accompanied by an increased ratio of sFit1 to PlGF. This forewarning should enable researchers to develop a diagnostic test that will allow healthcare providers to counter a major cause of maternal and fetal mortality worldwide.

Author: Kathryn Ayers

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