Gilbert's Syndrome Treatment Detroit MI

Should you worry about your GS? In Gilbert’s syndrome (GS), your liver loses some of its ability to eliminate bilirubin—a yellow pigment that results from the breakdown of red blood cells.

Satish Maryala, MD
(313) 745-3600
4201 Saint Antoine St Ste 5D
Detroit, MI
Specialties
Gastroenterology
Gender
Male
Education
Medical School: Bldea Sri Bm Patil Med Coll, Karnataka Univ, Bijapur, Karnataka
Graduation Year: 1993

Data Provided by:
Martin Tobi, MD
(313) 576-3416
4646 John R St
Detroit, MI
Specialties
Gastroenterology
Gender
Male
Education
Medical School: Univ Of Cape Town, Fac Of Med, Cape Town, So Africa
Graduation Year: 1976

Data Provided by:
Firdous Siddiqui, MD
(313) 745-8601
3990 John R Street 6 Hudson Harper Hospital
Detroit, MI
Specialties
Gastroenterology
Gender
Female
Education
Medical School: Gandhi Med Coll, Univ Hlth Sci, Vijayawada, Hyderabad, Ap, India
Graduation Year: 1990

Data Provided by:
Yakir Muszkat, MD
(313) 916-2600
2799 W Grand Blvd
Detroit, MI
Specialties
Gastroenterology, Internal Medicine
Gender
Male
Education
Medical School: Suny-Hlth Sci Ctr At Syracuse, Coll Of Med, Syracuse Ny 13210
Graduation Year: 1988

Data Provided by:
Ravi Nadimpalli
(313) 916-2408
2799 W Grand Blvd
Detroit, MI
Specialty
Gastroenterology

Data Provided by:
Kavita Mahakala, MD
540 E Canfield St Dept Med
Detroit, MI
Specialties
Gastroenterology
Gender
Female
Education
Medical School: Osmania Med Coll, Univ Hlth Sci, Vijayawada, Hyderabad, Ap, India
Graduation Year: 1988

Data Provided by:
Mohammed Z Abu Mahfouz, MD
(313) 916-2600
2799 W Grand Blvd
Detroit, MI
Specialties
Gastroenterology
Gender
Male
Education
Medical School: Yarmouk Univ, Fac Med, (Jordan Univ Sci & Tech), Irbid, Jordan
Graduation Year: 1992

Data Provided by:
Sadaf Khan, MD
(313) 916-2600
2799 W Grand Blvd
Detroit, MI
Gender
Female
Education
Medical School: Aga Khan Med Coll, Aga Khan Univ, Karachi, Pakistan
Graduation Year: 1992

Data Provided by:
Stuart Charles Gordon, MD
(248) 661-7889
2799 W Grand Blvd Ste K7
Detroit, MI
Specialties
Internal Medicine, Hepatology, Gastroenterology
Gender
Male
Education
Medical School: Wayne State Univ Sch Of Med, Detroit Mi 48201
Graduation Year: 1979
Hospital
Hospital: William Beaumont Hospital -Ro, Royal Oak, Mi
Group Practice: William Beaumont Hospital

Data Provided by:
Suhasini Macha, MD
(313) 745-5347
3901 Beaubien St
Detroit, MI
Specialties
Gastroenterology
Gender
Female
Education
Medical School: Wayne State Univ Sch Of Med, Detroit Mi 48201
Graduation Year: 1998

Data Provided by:
Data Provided by:

Ask the Doctor—Living with Gilbert's Syndrome

Provided by: 

By Robert Rountree, MD

Q After finding elevated bilirubin on a routine blood test, my doctor told me I had Gilbert’s syndrome, but it was nothing to worry about. Is that really true?

In Gilbert’s syndrome (GS), your liver loses some of its ability to eliminate bilirubin—a yellow pigment that results from the breakdown of red blood cells. A relatively common genetic condition, GS may affect as much as 10 to 20 percent of the population. Under normal conditions, the liver detoxifies bilirubin by combining it with a type of sugar called glucuronic acid in a process known as conjugation. The liver then releases the “conjugated” bilirubin into the bile ducts from whence it subsequently gets eliminated in the stool. For people with GS, the UGT1A1 enzyme that conjugates bilirubin works at only 20 to 70 percent of normal.

In a person with GS, situations that either increase the breakdown of red blood cells or overload the detoxifying ability of the liver can cause blood levels of “unconjugated” bilirubin to rise so high that the whites of her eyes will turn yellow—a condition called jaundice. This can occur with fasting, prolonged strenuous exercise, fatigue, surgery, infections, excessive alcohol intake, or menstruation.

Up until a few years ago, experts considered GS an innocuous condition, the only significant feature of which was abnormally high levels of unconjugated bilirubin on routine fasting blood tests. As it turns out, GS is not so benign: A significant percentage of people with this genetic abnormality also have an impaired ability to metabolize and excrete certain medications, including the pain-relieving drug acetaminophen (Tylenol) and a cancer chemotherapy agent called irinotecan. That makes them more susceptible to side effects, such as liver toxicity from acetaminophen or a severe drop in white blood cells from irinotecan. More recently, a groundbreaking study at the University of Washington in Seattle has shown that having a sluggish UGT1A1 enzyme can make it more difficult for people with the most severe form of GS to eliminate cancer-causing environmental toxins found in smoke, automotive exhaust, and charbroiled meat.

The study also reports another significant discovery, however: Eating a diet rich in cruciferous vegetables like broccoli, Brussels sprouts, cabbage and watercress can increase the activity of the UGT1A1 enyzme. (Onions, citrus fruits, and legumes also increase activity of the UGT1A1 enzyme, but not quite at the level as crucifers.) This implies that people with GS are particularly susceptible to the beneficial, cancer-preventive properties of broccoli and its edible relatives. Based on this research, I would recommend that you minimize the use of acetaminophen and avoid grilled meats, cigarette smoke, and exhaust fumes from petrochemical fuels as much as possible. In addition, eat at least one full serving of cruciferous vegetables every day. Or, if you aren’t particularly fond of this vegetable family, tr...

Author: Robert Rountree, MD

Copyright 1999-2009 Natural Solutions: Vibrant Health, Balanced Living/Alternative Medicine/InnoVisi...