Gilbert's Syndrome Treatment Des Moines IA

Should you worry about your GS? In Gilbert’s syndrome (GS), your liver loses some of its ability to eliminate bilirubin—a yellow pigment that results from the breakdown of red blood cells.

Nagendra V Myneni, MD
(515) 288-6097
2600 Grand Ave Ste 400
Des Moines, IA
Specialties
Gastroenterology
Gender
Male
Education
Medical School: Andhra Med Coll, Univ Hlth Sci, Visakhapatnam, Ap, India
Graduation Year: 1992

Data Provided by:
Michael Dennis O'Brien, MD
(515) 288-6097
2831 Forest Dr
Des Moines, IA
Specialties
Gastroenterology, Internal Medicine
Gender
Male
Education
Medical School: Tulane Univ Sch Of Med, New Orleans La 70112
Graduation Year: 1989

Data Provided by:
Stacey Roberts, MD
(515) 987-0437
2600 Grand Ave Ste 400
Des Moines, IA
Specialties
Gastroenterology
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
William Joseph Semon, DO
(515) 288-6097
2600 Grand Ave Ste 400
Des Moines, IA
Specialties
Gastroenterology, Internal Medicine
Gender
Male
Education
Medical School: Philadelphia Coll Of Osteo Med, Philadelphia Pa 19131
Graduation Year: 1977

Data Provided by:
Daniel Peasley, MR
(319) 758-9075
1223 S Gear Avenue Suite 201
Des Moines, IA
Specialties
Gastroenterology
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Wendell K Downing, MD FACS
5324 Robertson Dr
Des Moines, IA
Gender
Male
Education
Medical School: Iowa
Graduation Year: 1955

Data Provided by:
Daniel Dimeo
(515) 643-5442
330 Laurel St
Des Moines, IA
Specialty
Pediatric Gastroenterology

Data Provided by:
Ravi S Vemulapalli, MD
(515) 288-6097
2600 Grand Ave Ste 400
Des Moines, IA
Specialties
Gastroenterology
Gender
Male
Education
Graduation Year: 2007

Data Provided by:
Bernard Ira Leman, MD
(515) 288-6097
2600 Grand Ave Ste 400
Des Moines, IA
Specialties
Gastroenterology, Internal Medicine
Gender
Male
Education
Medical School: Tulane Univ Sch Of Med, New Orleans La 70112
Graduation Year: 1982
Hospital
Hospital: Mercy Med Ctr, Des Moines, Ia
Group Practice: Ia Digestive Disease Ctr Assoc; Mercy Medical Center Administration Office

Data Provided by:
Eduardo P Beltroy
(515) 241-6542
1212 Pleasant St
Des Moines, IA
Specialty
Pediatric Gastroenterology

Data Provided by:
Data Provided by:

Ask the Doctor—Living with Gilbert's Syndrome

Provided by: 

By Robert Rountree, MD

Q After finding elevated bilirubin on a routine blood test, my doctor told me I had Gilbert’s syndrome, but it was nothing to worry about. Is that really true?

In Gilbert’s syndrome (GS), your liver loses some of its ability to eliminate bilirubin—a yellow pigment that results from the breakdown of red blood cells. A relatively common genetic condition, GS may affect as much as 10 to 20 percent of the population. Under normal conditions, the liver detoxifies bilirubin by combining it with a type of sugar called glucuronic acid in a process known as conjugation. The liver then releases the “conjugated” bilirubin into the bile ducts from whence it subsequently gets eliminated in the stool. For people with GS, the UGT1A1 enzyme that conjugates bilirubin works at only 20 to 70 percent of normal.

In a person with GS, situations that either increase the breakdown of red blood cells or overload the detoxifying ability of the liver can cause blood levels of “unconjugated” bilirubin to rise so high that the whites of her eyes will turn yellow—a condition called jaundice. This can occur with fasting, prolonged strenuous exercise, fatigue, surgery, infections, excessive alcohol intake, or menstruation.

Up until a few years ago, experts considered GS an innocuous condition, the only significant feature of which was abnormally high levels of unconjugated bilirubin on routine fasting blood tests. As it turns out, GS is not so benign: A significant percentage of people with this genetic abnormality also have an impaired ability to metabolize and excrete certain medications, including the pain-relieving drug acetaminophen (Tylenol) and a cancer chemotherapy agent called irinotecan. That makes them more susceptible to side effects, such as liver toxicity from acetaminophen or a severe drop in white blood cells from irinotecan. More recently, a groundbreaking study at the University of Washington in Seattle has shown that having a sluggish UGT1A1 enzyme can make it more difficult for people with the most severe form of GS to eliminate cancer-causing environmental toxins found in smoke, automotive exhaust, and charbroiled meat.

The study also reports another significant discovery, however: Eating a diet rich in cruciferous vegetables like broccoli, Brussels sprouts, cabbage and watercress can increase the activity of the UGT1A1 enyzme. (Onions, citrus fruits, and legumes also increase activity of the UGT1A1 enzyme, but not quite at the level as crucifers.) This implies that people with GS are particularly susceptible to the beneficial, cancer-preventive properties of broccoli and its edible relatives. Based on this research, I would recommend that you minimize the use of acetaminophen and avoid grilled meats, cigarette smoke, and exhaust fumes from petrochemical fuels as much as possible. In addition, eat at least one full serving of cruciferous vegetables every day. Or, if you aren’t particularly fond of this vegetable family, tr...

Author: Robert Rountree, MD

Copyright 1999-2009 Natural Solutions: Vibrant Health, Balanced Living/Alternative Medicine/InnoVisi...